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Clinical Profile: Narcolepsy Narcolepsy is a disabling neurological disorder of sleep regulation that affects the control of sleep and wakefulness. It may be described as an intrusion of the dreaming state of sleep REM or rapid eye movement sleep ; into the waking state Symptoms Symptoms generally begin between the ages of 15 and 30 The four classic symptoms of the disorder are : ! Excessive daytime sleepiness: Unrelenting excessive sleepiness is usually the first and most prominent symptom of narcolepsy. Patients with the disorder experience irresistible sleep attacks, throughout the day, which can last for 30 seconds to more than 30 minutes, regardless of the amount or quality of prior nighttime sleep. These attacks result in episodes of sleep at work and social events, while eating, talking and driving, and in other similarly inappropriate occasions ! Cataplexy sudden, brief episodes of muscle weakness or paralysis brought on by strong emotions such as laughter, anger, surprise or anticipation ; ! Sleep paralysis paralysis upon falling asleep or waking up ; ! Hypnagogic hallucinations vivid dream-like images that occur at sleep onset ; Disturbed nighttime sleep, including tossing and turning in bed, leg jerks, nightmares, and frequent awakenings, may also occur The development, number and severity of symptoms vary widely among individuals with the disorder It is probable that there is an important genetic component to the disorder as well Treatment There is no cure for narcolepsy; however, the symptoms can be controlled with behavioral and medical therapy The excessive daytime sleepiness may be treated with stimulant drugs or with the drug modafinil Provigil ; , which is approved by the FDA Cataplexy and other REM-sleep symptoms may be treated with antidepressant medications At best, medications will reduce the symptoms, but will not alleviate them entirely Basic lifestyle adjustments such as regulating sleep schedules, scheduled daytime naps and avoiding "over-stimulating" situations may also help to reduce the intrusion of symptoms into daytime activities Prognosis Although narcolepsy is a life-long condition, most individuals with the disorder enjoy a near-normal lifestyle with adequate medication and support from teachers, employers, and families, for example, avapro 50.

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Avapro contraindications Our avapro irbesartan ; monograph this avapro irbesartan ; monograph is presented courtesy of avapro generic name: irbesartan pronounced: er-bah-sar-tan drug class: antihypertensive, ace ii inhibitor important note: the following information is only intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional familiar with your condition. Information about avapro 150mg Corticosteroids are produced naturally by the body itself but if there aren't enough of them, the doctor prescribes the medicine and ceftin and avapro, for instance, avapro weight gain. Product liability litigation Pre-clinical and clinical trials are conducted during the development of potential products to determine the safety and efficacy of products for use by humans following approval by regulatory bodies. Notwithstanding these efforts, when drugs and vaccines are introduced into the marketplace, unanticipated side effects may became evident. The Group is currently a defendant in a number of product liability lawsuits, including class actions, that involve substantial claims for damages related to the Group's pharmaceutical products. Litigation, particularly in the USA, is inherently unpredictable and excessive verdicts that are not justified by the evidence can occur. Class actions that sweep together all persons who were prescribed the Group's products can inflate the potential liability by the force of numbers. Claims for pain and suffering and punitive damages are frequently asserted in product liability actions and, if allowed, can represent potentially open-ended exposure. Anti-trust litigation In the USA it has become increasingly common that following an adverse outcome in prosecution of patent infringement actions, the defendants and direct and indirect purchasers and other payers initiate anti-trust actions as well. Claims by direct and indirect purchasers and other payers are typically filed as class actions and the relief sought may include treble damages and restitution claims. Damages in adverse anti-trust verdicts are subject to automatic trebling in the USA. Governmental investigations The Group operates globally in complex legal and regulatory environments that often vary among jurisdictions. The failure to comply with applicable laws, rules and regulations in these jurisdictions may result in civil and criminal legal proceedings. In the USA, for example, the Group is responding to federal and state governmental investigations into pricing, marketing and reimbursement of its prescription drug products. These investigations could result in related restitution or civil false claims act litigation on behalf of the federal or state governments, as well as related proceedings initiated against the Group by or on behalf of consumers and private payers. Such proceedings may result in trebling of damages awarded or fines in respect of each violation of law. Criminal proceedings may also be initiated against Group companies or individuals. Risks of competition, price controls and limitations on sales Third party competition The Group operates in highly competitive businesses. In the pharmaceuticals business, it faces competition both from proprietary products of large international manufacturers and producers of generic pharmaceuticals. Significant product innovations, technical advances or the intensification of price competition by competitors could adversely affect the Group's operating results. Continued consolidation in the pharmaceutical industry could adversely affect the Group's competitive position, while continued consolidation among the Group's customers may increase pricing pressures.

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