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Although rare, CTCLs are disfiguring and symptomatic. Early diagnosis of MF is elusive, and once made, no curative therapy currently exists. Mycosis fungoides may have an indolent course with long-standing skin involvement or may progress to aggressive systemic and lethal lymphoma.1, 25, 26, 28, Only a few of the available therapies for MF and CTCL are approved by the Food and Drug Administration FDA most have cumulative toxic effects over time.33, 34, 63 A randomized, National Cancer Institutesponsored study conducted in the 1980s demonstrated that multidrug chemotherapy was no better than sequential conservative topical therapy in prolonging overall survival, despite a slightly higher initial response rate.31 Patients with early-stage MF who either fail to respond to or relapse after skin-directed therapies require administration of systemic agents, and biological response modifiers cytokines or retinoids ; are favored for disease control.1, 30, 32-34, 66, Bexarotene is the first of a new class of agents the rexinoids ; that are selective for RXRs. As with retinoids, bexarotene is contraindicated in pregnant women or in women planning pregnancy. Bexaro REPRINTED ; ARCH DERMATOL VOL 137, MAY 2001 590, for example, oxycodone 512.
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Page 5 943 So. 2d 919; 2006 Fla. App. LEXIS 20376, * 15; 31 Fla. L. Weekly D 3021 circumstances that Mr. Paey relies upon to argue that his sentences are unconstitutional do not persuade us to engage in "the basic line-drawing process that is 'properly within the province of legislatures, not courts.' " Hutto, 454 U.S. at 374 quoting Rummel, 445 U.S. at 275-76 ; . At oral argument, the State directed our attention to Henderson v. Norris, 258 F.3d 706 8th Cir. 2001 ; , in which the Eighth Circuit held that a life sentence for the delivery of .238 grams of cocaine base violated the Eighth Amendment. n2 We conclude that the facts in Henderson are distinguishable from the facts in Mr. Paey's case. As [ * 16] described by the Eighth Circuit, the amount of drugs that Henderson sold was "extraordinarily small, " weighing "less than one-quarter of a gram." Id. at 710. Here, the amount of oxycodone which Mr. Paey possessed that was sufficient to qualify him for each of his seven trafficking convictions was not extraordinarily small. Florida's statutory scheme fixes the severity of the punishment for trafficking offenses to three categories determined by the weight of the illegal substance involved. Under section 893.135 1 ; c ; 1 ; , the three weight categories are: 1 ; four to fourteen grams, 2 ; fourteen to twenty-eight grams, and 3 ; twenty-eight grams to thirty kilograms. See 893.135 1 ; c ; 1 ; Mr. Paey's convictions for trafficking were based on his possession of thirty-three grams of oxycodone for each illegal prescription that he had filled. n3 Because the amount of oxycodone that Mr. Paey possessed fell into the highest weight category under subsection 1 ; c ; 1 ; , cannot conclude that Mr. Paey possessed such an extraordinarily small amount of oxycodone that his crime should not be considered severe. n2 We commend John M. Klawikofsky, the assistant attorney general who argued this case for the State, for his professionalism in calling to our attention an authority that could be interpreted as being adverse to the State's position. [ * 17] Mr. Paey's case is also distinguishable from Henderson based on the type of sentence imposed. Henderson was sentenced to life imprisonment. 258 F.3d at 707. According to the Eighth Circuit, the life sentence meted out to Henderson was the harshest sentence that could then be imposed in Arkansas, other than a death sentence for the crimes of capital murder and treason. Id. at 711. In Arkansas, an offender sentenced to life imprisonment was not eligible for parole unless the governor commuted the sentence to a term of years in the exercise of clemency. Id. The Eighth Circuit used this fact to liken Henderson's case to Solem, the only Supreme Court case declaring a term of imprisonment unconstitutional. Id. at 711-12. In Solem, the Supreme Court discussed the difference between the [ * 18] normal expectation of parole eligibility and the bare possibility of commutation. 463 U.S. at 300-03. The Court relied on this difference to distinguish the life sentence without possibility of parole imposed in Solem from the life sentence with possibility of parole upheld in Rummel and to hold that the life sentence without possibility of parole was disproportionate. Id. at 303. Based on the analysis in Solem, the Henderson court concluded that Henderson's life imprisonment sentence was grossly disproportionate to the crime he committed. 258 F.3d at 711-12. Mr. Paey's case is distinguishable from Henderson's because Mr. Paey did not receive a life sentence. Mr. Paey's twenty-five-year mandatory minimum sentences are considerably less severe than a life sentence with the possibility of parole and are substantially less severe than a life sentence without the possibility of parole, which appears to have been imposed in Henderson. Because of the substantial difference in the facts of the two cases, we find Henderson to be unpersuasive on the Eighth Amendment issue in Mr. Paey's case. The twenty-five-year mandatory [ * 19] minimum prison sentence the Florida Legislature prescribed in section 893.135 1 ; c ; 1 ; for trafficking in twenty-eight or more grams of oxycodone falls within the outer limits of a rational weighing of the alternatives concerning an appropriate prison term for this offense. This is not one of those rare cases in which the sentence imposed is so grossly disproportionate in comparison to the crime committed that it is cruel and unusual. For this reason, we hold that Mr. Paey's sentences for trafficking in oxycodone do not violate the Eighth Amendment's prohibition against cruel and unusual punishments.
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14. Britten CD, Pegram M, Rosen P, et al. Targeting ErbB receptor interactions: a phase I trial of trastuzumab and erlotinib in metastatic HER2 + breast cancer. Proc Soc Clin Oncol 2004; 23: 206 abstract 3045 ; . 15. Storniolo AM, Burris HA III, Overmoyer B, et al. A phase I, open-label study of the safety, tolerability and pharmacokinetics of lapatinib GW572016 ; in combination with trastuzumab. Breast Cancer Res Treat 2005; 94 suppl 1 ; : S64 abstract 1073 ; . 16. Sansal I, Sellers WR. The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004; 22: 2954-63. Nagata Y, Lan K-H, Zhou X, et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell 2004; 6: 117-27. Modi S, Stopeck A, Gordon MS, et al. Trastuzumab T ; and KOS-953 17-AAG ; is feasible and active in patients pts ; with metastatic breast cancer: preliminary results of a phase 1 2 study. Breast Cancer Res Treat 2005; 94 suppl 1 ; : S72 abstract 1095.
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1. Galema, S. A. Chem. Soc. Rev. 1997, 26, 233-238. Gabriel, C.; Gabriel, S.; Grant, E. H.; Halstead, B. S. J.; Mingos, D. M. P. Chem. Soc. Rev. 1998, 27, 213. Gedye, R. et al. The use of microwave ovens for rapid organic synthesis. Tetrahedron Lett. 1986, 27, 279-282. Giguere, R. J. et al. Application of commercial microwave ovens to organic synthesis. Tetrahedron Lett. 1986, 27, 4945-4948. Langa, F. et al. Microwave irradiation: more than just a method for accelerating reactions. Contemp. Org. Synth. 1997, 4, 373-386. Gedye, R. N., Wei, J. B. Rate enhancement of organic reactions by microwaves at atmospheric pressure. Can. J. Chem. 1998, 76, 525-532. Pagnotta, M.; Pooley, C. L. F.; Gurland, B.; Choi, M. J. Phys. Org. Chem. 1993, 6, 407-411. Perreux L., Loupy A. A tentative rationalization of microwave effects in organic synthesis according to the reaction medium and mechanistic considerations. Tetrahedron, 2001, 57, 9199-9223. Hayes, B. L., Microwave Synthesis: Chemistry at the Speed of Light, CEM Publishing: Matthews, NC 2002. 10. Stuerga, D.; Gonon, K.; Lallemant, M. Tetrahedron 1993, 49, 6229-6234. Baghurst, D. R.; Mingos, D. M. P. Superheating effects associated with microwave dielectric heating. J. Chem. Soc. Chem Commun. 1992, 674-677. 12. a ; Dzierba, C. D.; Combs, A. P. Microwave-Assisted Chemistry as a Tool for Drug Discovery. Annual Reports in Medicinal Chemistry 2002, 37, 247-256. b ; Santagada, V.; Perissutti, E; Caliendo, G. The Application of Microwave Irradiation as New Convenient Synthetic Procedure in Drug Discovery. Curr. Med. Chem. 2002, 9, 1251-1284. c ; Wathey, B.; Tierney, J.; Lidstrm, P. Westman, J. The Impact of Microwave-Assisted Organic Chemistry on Drug Discovery. Drug Discovery Today, 2002, 7, 373-380. d ; Wilson, N.S.; Roth, G. P. Recent Trends in Microwave-Assisted Synthesis. Curr. Opin. Drug Disc. & Dev. 2002, 5 4 ; , 620-629. e ; Larhed, M; Hallberg, A. Microwave-Assisted High Speed Chemistry: A New Technique in Drug Disvovery. Drug Discovery Today 2001, 6, 406-416. f ; Kappe, C. O. High Speed Combinatorial Synthesis utilizing Microwave Irradiation. Curr. Opin. Chem. Bio. 2002, 6 3 ; , 314-320. g ; Larhed, M.; Moberg, C.; Hallberg, A. Microwave-Accelerated Homogenous Catalysis in Organic Chemistry. Acc. Chem. Res. 2002, 35 9 ; , 717-727. h ; Lidstrm, P.; Tierney, J.; Wathey, B.; Westman, J. Microwave-Assisted Organic Synthesis-A Review. Tetrahedron, 2001, 57, 9225-9283. i ; Lidstrm, P., Westman, J., Lewis A. Enhancement of Combinatorial Chemistry by Microwave-Assisted Organic Synthesis. Comb Chem. High Throughput Screen. 2002, 5, 441-458. j ; Lidstrm, P.; Tierney, J. P. ed ; Microwave Assisted Organic Synthesis. Blackwell Publishing, Oxford, UK 2005. 13. Sarko, C. Timesavings associated with microwave-assisted synthesis: a quantitative approach, in Lidstrm, P.; Tierney, J. P., Ed ; Microwave Assisted Organic Synthesis. Blackwell Publishing Oxford, UK 2005.
References: 1. 2. 3. Litovitz TL, Klein-Schwartz W, Rodgers GC, Jr., et al. 2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. J Emerg Med 2002; 20: 391-452. Hollister LE. Tricyclic antidepressants first of two parts ; . N Engl J Med 1978; 299: 1106-9. Lipsey JR, Robinson RG, Pearlson GD, Rao K, Price TR. Nortriptyline treatment of post-stroke depression: a double-blind study. Lancet 1984; 1: 297-300. Hamalainen ML. Migraine in children - Guidelines for treatment. Cns Drugs 1998; 10: 105-117. Sharav Y, Singer E, Schmidt E, Dionne RA, Dubner R. The analgesic effect of amitriptyline on chronic facial pain. Pain 1987; 31: 199-209. Watson CP, Evans RJ, Reed K, Merskey H, Goldsmith L, Warsh J. Amitriptyline versus placebo in postherpetic neuralgia. Neurology 1982; 32: 671-3. Liebowitz MR. Antidepressants in panic disorders. Br J Psychiatry Suppl 1989: 46-52. Linder MW, Prough RA, Valdes R, Jr. Pharmacogenetics: a laboratory tool for optimizing therapeutic efficiency. Clin Chem 1997; 43: 254-66. Balant-Gorgia AE, Balant LP, Garrone G. High blood concentrations of imipramine or clomipramine and therapeutic failure: a case report study using drug monitoring data. Ther Drug Monit 1989; 11: 415-20. Jannetto PJ, Wong SH, Gock SB, Laleli-Sahin E, Schur BC, Jentzen JM. Pharmacogenomics as molecular autopsy for postmortem forensic toxicology: genotyping cytochrome P450 2D6 for oxycodone cases. J Anal Toxicol 2002; 26: 438-47. Baselt R. Disposition of toxic drugs and chemicals in man. Foster city: Biomedical Publications, 2002. Ghahramani P, Ellis SW, Lennard MS, Ramsay LE, Tucker GT. Cytochromes P450 mediating the Ndemethylation of amitriptyline. Br J Clin Pharmacol 1997; 43: 137-44. Apple FS, Bandt CM. Liver and blood postmortem tricyclic antidepressant concentrations. J Clin Pathol 1988; 89: 794-6 and phenergan.
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Reinstate the trial court's order denying dismissal. The central issue is whether Travis could be properly charged and sentenced under the drug trafficking statute if the total weight of the controlled substance alone does not trigger the four-gram limit. The trafficking statute at issue, section 893.135 1 ; c ; 1, Florida Statutes 1997 ; , provides in relevant part: Any person who knowingly sells, purchases, manufactures, delivers, or brings into this state, or who is knowingly in actual or constructive possession of, 4 grams or more of any morphine, opium, oxycodone, hydrocodone, hydromorphone, or any salt, derivative, isomer, or salt of an isomer thereof, including heroin, as described in s. 893.03 1 ; b ; or grams or more of any mixture containing any such substance, but less than 30 kilograms of such substance or mixture, commits a felony of the first degree, which felony shall be known as "trafficking in illegal drugs." Emphasis added. ; This Court in Hayes v. State, 750 So. 2d 1 Fla. 1999 ; , indicated that the term "any mixture containing any such substance" referred to the substances listed in schedules I and II only. We opined that: [T]he Fourth District focused on the meaning of "mixture" in concluding that it was not the amount of hydrocodone per dosage unit but the aggregate weight of the tablets seized which controlled. See Hayes, 720 So. 2d at 1097. We, however, conclude that the statute must be read strictly with the focus on the term "such, " which restricts the phrase "any mixture, " by referring back to the restrictive phrase "as described in s. 893.03 1 ; b ; [Schedule I] or 2 ; [Schedule II]." Thus, a close reading of the statutory language reveals that "such mixture" applies only to mixtures containing Schedule I or II substances and plendil.
Information received from the drug abuse warning network dawn ; indicates that instances of emergency department episodes and medical examiners reports involving oxycodone, the active ingredient in oxycontin , have increased significantly since 199 reports from 20 metropolitan areas within the continental indicate that oxycodone-related deaths and emergency department episodes have increased 400 percent and 100 percent, respectively.
Section 300.610 Resident Care Policies a ; The facility shall have written policies and procedures, governing all services provided by the facility which shall be formulated by a Resident Care Policy Committee consisting of at least the administrator, the advisory physician or the medical advisory committee and representatives of nursing and other services in the facility. These policies shall be in compliance with the Act and all rules promulgated thereunder and potassium.
Before taking lorazepam, tell your doctor if you are using any of the following drugs: a barbiturate such as amobarbital amytal ; , butabarbital butisol ; , mephobarbital mebaral ; , secobarbital seconal ; , or phenobarbital luminal, solfoton an mao inhibitor such as isocarboxazid marplan ; , phenelzine nardil ; , rasagiline azilect ; , selegiline eldepryl, emsam ; , or tranylcypromine parnate medicines to treat psychiatric disorders, such as chlorpromazine thorazine ; , haloperidol haldol ; , mesoridazine serentil ; , pimozide orap ; , or thioridazine mellaril narcotic medications such as butorphanol stadol ; , codeine, hydrocodone loratab, vicodin ; , levorphanol levo-dromoran ; , meperidine demerol ; , methadone dolophine, methadose ; , morphine kadian, ms contin, oramorph ; , naloxone narcan ; , oxycorone oxycontin ; , propoxyphene darvon, darvocet or antidepressants such as amitriptyline elavil, etrafon ; , amoxapine ascendin ; , citalopram celexa ; , clomipramine anafranil ; , desipramine norpramin ; , doxepin sinequan ; , escitalopram lexapro ; , fluoxetine prozac, sarafem ; , fluvoxamine luvox ; , imipramine janimine, tofranil ; , nortriptyline pamelor ; , paroxetine paxil ; , protriptyline vivactil ; , sertraline zoloft ; , or trimipramine surmontil.
How to do a drug challenge on an adult patient. Using the chart on page 12 of this chapter start the drug challenge. Decide which TB drugs the patient was taking when they had the reaction. Ignore the columns that apply to drugs that the patient was not taking. Make sure that the correct dose of the correct drug s ; are given at the same time every day and that the patient is re-examined for any signs of a reaction just before the next dose is given. Make sure that a health worker every day, 2 - 3 hours after taking the dose, examines the patient. If the patient is sensitive to this drug a slight skin rash or fever will develop. If the health worker is concerned about a possible reaction he she will inform the senior health worker or doctor. If no allergic reaction has occurred within 24 hours of the test dose, give the next dose according to the chart. Again watch for rash fever itching 2-3 hours later. Continue in this way, following the chart, until all the drugs have been restarted OR a reaction occurs. If a reaction occurs inform the senior health worker or doctor. STOP THAT DRUG and ensure that it is crossed out from the rest of that patient's drug challenge chart. RECORD THE DRUG REACTION IN RED ON THE PATIENT'S DRUG CHART, MEDICAL NOTES, TB CARD and PATIENT HELD CARDS. The following day, if the reaction has settled, continue with the next drug to be tested according to the chart. If the reaction hasn't yet settled then continue with the previous stage of the drug challenge without the drug that reacted ; until the reaction settles. Continue with those TB drugs that you have already tested and which you know have not caused a reaction and pravachol and oxycodone, for instance, taking oxycodone.
Foreign Assistance Act US ; , 114 formularies insurance and, 147 third party payer systems and, 147 Forum for Collaborative HIV Research, 298 foundations Bill and Melinda Gates Foundation, 11 FP6 sixth research framework program ; , 119 in EU, 119 FPC Fair Pricing Coalition ; , 311 France cloning limits in, 119 innovation output in, 333334 stem cell research in, 119 Francis, Tommy, 386 Franklin, Ben, 378 Franklin v. Parke-Davis FCA and, 191193, 194 "off-label" promotion and, 191 Frazier, Kenneth, 14 frozen embryo transfer. See FET funding source s ; for AIDS activism, 318 for clinical trials, 4546, 322324 EU Directive on Clinical Trials and, 45 foundations as, 322 GCP guidelines for, 45 governments, 322 ICH and, 45 for multiple perspectives systems, 277 pharmaceutical industry as, 323 responsibilities of, 46 for tropical diseases, by nation, 31 WHO and, 45 Gallup polls, 4 gamete intrafallopian transfer. See GIFT Garber, Alan, 246 Gathii, James, 259, 379 GCP Guidelines for Good Clinical Practice for Trials on Pharmaceutical Products ; funding sponsor obligations for, 45 patient selection and, 70 WHO and, 37, 40, 43.
Antidepressants -- TCAs Amitriptyline - Elavil 1 ; 1. 2. Cyclobenzaprine - Flexeril 2 ; 1. 2. Desipramine - Norpramin 3 ; 1. 2. Doxepin - Sinequan 4 ; 1. 2. Antidepressants -- SSRIs, SNRIs, and related many are also alerting agents ; Bupropion - Wellbutrin 7 ; 1. 2. Citalopram - Celexa 8 ; 1. 2. Duloxetine - Cymbalta 9 ; 1. 2. Escitalopram - Lexapro 10 ; 1. 2. Fluoxetine - Prozac 11 ; 1. 2. Fluvoxamine - Luvox 12 ; 1. 2. Mirtazapine - Remeron 13 ; 1. 2. Olanzapine - Zyprexa 14 ; 1. 2. Paroxetine - Paxil 15 ; 1. 2. Sertraline - Zoloft 16 ; 1. 2. Venlafaxine - Effexor 17 ; 1. 2. Opioids Codeine - Tylenol 3 or 4 Fentanyl - Duragesic patch 19 ; 1. 2. Hydrocodone - Vicodin, Lortab 20 ; 1. 2. Hydromorphone - Dilaudid 21 ; 1. 2. Methadone - Dolophine 22 ; 1. 2. Morphine - MS Contin, Kadian, Oramorph 23 ; 1. 2. short-acting - MS-IR 24 ; 1. 2. 3. Oxycdoone - OxyContin 25 ; 1. 2. short-acting - Oxy-IR, Percocet, Roxicet 26 ; 1. 2. Oxymorphone - Numorphan 27 ; 1. 2. Pentazocine - Talwin 28 ; 1. 2. Propoxyphene - Darvacet 29 ; 1. 2. Tramadol - Ultram 30 ; 1. 2. with Tylenol - Ultracet 31 ; 1. 2. Anti-epileptic drugs Gabapentin - Neurontin 32 ; 1. 2. Lamotrigine - Lamictal 33 ; 1. 2. Pregabalin - Lyrica 34 ; 1. 2. Tiagabine - Gabatril 35 ; 1. 2. Topiramate - Topamax 36 ; 1. 2. Zonisamide - Zonegran 37 ; 1. 2. Muscle relaxants Baclofen - Lioresal 38 ; 1. 2. Carisoprodol - Soma 39 ; 1. 2. Dantrolene - Dantrium 40 ; 1. 2. Metaxalone - Skelaxin 41 ; 1. 2. Tizanidine - Zanaflex 42 ; 1. 2. Anti-inflammatories Diclofenac - Voltaren 43 ; 1. 2. Ibuprofen - Motrin, Advil 44 ; 1. 2. Indomethacin - Indocid 45 ; 1. 2. Ketoprofen - Orudis, Oruvial 46 ; 1. 2. Naproxen - Aleve 47 ; 1. 2. Note: Some sleep aids are listed in the Pain section. ; Hypnotics Eszopiclone - Lunesta 48 ; 1. 2. Zaleplon - Sonata 49 ; 1. 2. Zolpidem - Ambien 50 ; 1. 2. Benzodiazepines Alprazolam - Zanax 51 ; 1. 2. Clonazepam - Klonopin 52 ; 1. 2. Diazepam - Valium 53 ; 1. 2. Lorazepam - Ativan 54 ; 1. 2. Sodium Oxybate - Xyrem 60 ; 1. 2. Trazodone - Desyrel 61 ; 1. 2. many alerting agents are listed under pain meds ; Atomoxetine - Strattera 62 ; 1. 2. D-ampthetamine - Adderall 63 ; 1. 2. Methylphenidate - Concerta, Metadate 64 ; 1. 2. Modifinil - Provigil 65 ; 1. 2. Thank you for identifying the medications that you had adverse reactions to. Now, FM Network would like to know which medications have benefited you the most up to a total of seven ; . This information, combined with the first section, will provide Network Members with a better cost benefit picture e.g., side effects versus symptom improvements ; for each medication. As you probably noticed, after each of the medications above, there is a number in parentheses. Read through the list above and jot down the numbers of those drugs that have been the most useful for treating your FMS CFS. Then write their numbers in the spaces below, with the first line being the most beneficial, the second line being the second most helpful, etc. You may enter a maximum of seven different numbers, with each representing a different drug. Leave any unused lines blank if you have less than seven drugs to list and prednisone.
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The defendant, Doryel West, acting in concert with another person known to the grand jury, identified as ZY60000K in the State of New York, in the County of Bronx, on or about September 12, 2002, intentionally aided said person to knowingly and unlawfully possessed one or more preparations, compounds, mixtures or substances are of an aggregate weight of more than four ounces containing a narcotic drug, to wit: Oxycodone. COUNT 88 THE GRAND JURY OF THE COUNTY OF BRONX, by this indictment, accuses the defendant of the crime of CRIMINAL POSSESSION OF A CONTROLLED SUBSTANCE IN THE FIRST DEGREE in violation of Section 220.21 1 ; of the Penal Law, committed as follows and oxycontin.
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Table 1: Demographic and clinical with intussusception Clinical data Blood in the stool Fever Associated disease None Gastroenteritis Upper respiratory tract infection Trauma Site of intussusception Hepatic flexure Transverse colon Splenic flexure Beyond Splenic flexure data of patients n % ; 42 64 ; 45.5 ; 20 30 ; 15.
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Back to the top 13: Not delivered to the top 14: Saturday 10th May, 2003 09.30 - 10.00 h. FREESTANDING PAPER TITLE: Medical Errors in General Practice. Results of the PCISME Study in Germany AUTHOR S ; : Martin Beyer Meike Reh Ferdinand M. Gerlach Susan Dovey Institute for General Practice, University of Kiel, Germany ADDRESS: Instit. Allgemeinmedizin - Arnold Hellerstr. 10 24105 Kiel, Germany E-mail: Beyer allgemeinmedizin -kiel Background: Following the Institute of Medicine's report 1999 ; errors in medicine have internationally become a problem of highest interest. Little research has been done on errors in general practice. Co-ordinated by the Robert Graham Center American Academy of Family Physicians ; , an international exploratory study was performed in seven countries US, Canada, Australia, New Zealand, UK, The Netherlands, and Germany ; . Results of the German part of the study will be reported. Objectives: To test the feasibility of registering errors in general practice, to demonstrate the feasibility of a secured anonymous registration system, to classify types of errors and contributing factors following an international four-digit taxonomy of medical errors.
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